From lush rainforests that are ripe for adventurous hikes, to vibrant history-rich cities, and sublime beaches and islands, there’s a whole lot more to Panama than its world-famous engineering marvel. And the good news is, it’s perfectly possible to soak up this colorful country’s diverse landscapes, wildlife and culture if you’re short on time. With that in mind, read on for a Panama itinerary created by our very own Panama travel experts.
As revealed in our run-down of things you didn't know you could do in Panama, the country packs a lot into the narrow strip of land that falls within its borders.
This 10 days Panama itinerary gives you the full Panama experience, balancing urban adventures with nature and a bit of adrenaline. Start in vibrant Panama City, then head to the lush volcanic valley of El Valle de Anton.
From there, head to the cool, coffee-scented highlands of Boquete before finishing in the tropical paradise of Bocas del Toro. If you're trip planning to Panama, this itinerary gives you a perfect taste of the best places to visit in Panama — from bustling city life to lush mountains and idyllic beaches. It’s an ideal first-time trip, offering adventure and relaxation without feeling rushed.
While planning your Panama vacation itinerary, Central America's most modern capital deserves special attention. Start in Casco Viejo, the city's historic heart. Wander cobblestone streets lined with colonial buildings, trendy rooftop bars, and artisan shops.
Make time for the Biomuseo, a bold, colorful structure by Frank Gehry, which tells the story of Panama's biodiversity.
And of course, visit the Miraflores Locks at the Panama Canal to watch massive ships maneuver through this engineering wonder. The city's unique location—at the narrowest part of the isthmus—made it the ideal spot to connect two oceans.
Next destination: Panama City → El Valle de Anton (3 hours by bus from Albrook Terminal)
Panama city is an absolute must for any Panama itinerary © Shutterstock
El Valle de Anton sits in the crater of an extinct volcano, giving it a cool, refreshing climate and an otherworldly feeling.
This unusual setting is home to rare Panamanian wildlife, including the elusive golden frog. Early settlers were drawn here by the fertile soil and mild weather, and you'll see why. Spend your days hiking to the Chorro El Macho waterfall, browsing the colorful local market, or relaxing in thermal pools. For the best views, tackle one of the nearby mountain trails.
Next destination: El Valle → Boquete (7 hours total: El Valle to David, then David to Boquete)
Tucked into the Chiriquí Highlands, Boquete is a hotspot for adventure and some of the best coffee in the world, including the famous Geisha variety. Tour a coffee farm to see how it's grown and processed, hike the rugged Baru Volcano, or tackle the rapids on a white-water rafting trip.
Boquete's high altitude and nutrient-rich soil are the secret to its exceptional coffee, making it a must-visit for coffee enthusiasts and a fantastic stop on any Panama vacation. This is also a great place for a hike: see our beginners guide to the Panama rainforest.
Next destination: Boquete → Bocas del Toro (5-6 hours total: bus from Boquete to Almirante, then water taxi)
This Caribbean archipelago is a collection of islands known for crystal-clear waters, coral reefs, and easygoing vibes. It's a region rich in history, from its indigenous Ngäbe-Buglé roots to its time as a key port for the banana trade. Stay on Isla Colón and venture out to nearby gems: relax on Red Frog Beach (one of the best beaches in Panama), snorkel at Coral Cay, and keep an eye out for dolphins in Dolphin Bay. The calm waters here are a haven for marine life, making it a dream for snorkelers and divers alike.
Canopy Tree Trek in Boquete, Panama © Shutterstock
The first views of Panama you're likely to see on your Panama trip © Nori Jemil
Duration: Around 7 days
What to do in Panama for a week? If beaches and turquoise waters are your idea of a dream trip, this 7 days in Panama itinerary is for you. You'll start with a few days in Panama City to soak up some culture and history, then head straight to the Caribbean for an extended stay in Bocas del Toro. It's the kind of trip where travel time takes a back seat to hammock time, perfect for anyone looking to snorkel, dive, or simply enjoy the rhythm of island life.
You'll get more out of Panama City with a little extra time to dig deeper. Beyond the must-sees, check out Metropolitan Natural Park, a tropical forest in the heart of the city where you might spot sloths or toucans.
Then, head to the Amador Causeway, an iconic stretch built with earth excavated from the Panama Canal. It's great for walking or biking and gives you a panoramic view of the city skyline. While you're there, don't miss the Biodiversity Museum, a colorful landmark designed by Frank Gehry. The causeway also connects to three small islands, offering a unique vantage point for watching ships approach the canal.
Next destination: Panama City → Bocas del Toro (1 hour by evening flight)
As you plan what to do in Panama for a week or longer, Bocas is a must-visit destination. With four days, you'll have plenty of time to dive into everything this Caribbean gem has to offer. Spend a day at the Zapatillas Cays, two picture-perfect islands inside Bastimentos Marine National Park, ideal for swimming, snorkeling, or just lounging on untouched beaches.
Visit Isla Solarte to learn about the indigenous Ngäbe-Buglé community and enjoy some of the area's quietest spots. If surfing is your thing, Carenero Island has breaks for every level. Each island offers something a little different—calm bays for relaxing swims, vibrant reefs for snorkeling, or exposed waters for riding waves.
Approaching one of the many islands in Panama © Nori Jemil
View of Bocas Town from the waterfront: a fantastic place to go on any Panama itinerary
Duration: Around 5 days
If you're short on time but still want a tropical escape with a cultural twist, this 5 days Panama travel itinerary is for you. It's designed to make the most of your trip without feeling rushed. You'll start with the buzz of Panama City, then trade the urban energy for the relaxed vibe of Taboga Island. It's perfect for a long weekend or a quick break, and it works well year-round.
Your quick Panama travel adventure kicks things off in Panama City, where history and modernity meet. Of course, you'll want to visit Casco Viejo, with its charming streets, rooftop bars, and historic sites, and the Panama Canal to see one of the world's engineering marvels in action.
But don't stop there — head to the Fish Market (Mercado de Mariscos), where you can sample ultra-fresh ceviche from local vendors. In the evening, take a stroll along the Cinta Costera, a scenic waterfront promenade with fantastic views of the city's skyline. This pathway is more than just a pretty walk: it was built to provide green space while easing city traffic.
Next destination: Panama City → Taboga Island (30 minutes by ferry from Amador Causeway)
Just a stone's throw from the city, Taboga Island, also known as the "Island of Flowers," feels like a hidden oasis. Its history runs deep, from Spanish conquistadors using it as a rest stop to its role in the Panama Canal's construction era. Even Paul Gauguin spent time recovering here.
Once you arrive, you'll find peaceful beaches, easy hiking trails, and a quaint village with a beautiful colonial church. Spend your days lounging on the sand, wandering the island's quiet streets, or hiking up Cerro de la Cruz for panoramic views of the Pacific. Despite being so close to the city, Taboga's tranquil vibe makes it feel like you've traveled much farther.
Women in the national pollera dress, Panama © Nori Jemil
Views before landing in Playon Chico, Panama © Nori Jemil
Or, if you’re still making up your mind, browse our customizable Panama itineraries for inspiration, and contact our local expert.
From travel safety to visa requirements, discover the best tips for visiting Panama
written by
Joanne Owen
updated 05.03.2025
