This four- to five-week trip takes in dramatic Andean landscapes, colonial cities and former Jesuit missions, colourful fiestas, ancient sites and Amazonian rainforests.
1 La Paz
The world's highest de facto capital city is also one of its most compelling, a riot of indigenous colour, vertiginous markets and street protests.
Though a mere fraction of this iconic pre-Columbian, pre-Incan city has been excavated, its mysterious, monumental slabs of sandstone are a must-see.
3 Lago Titicaca
A vast, striking blue expanse standing at 3810m, the lake is dotted with sacred islands and surrounded by snow-capped mountains.
4 Salar de Uyuni and the Reserva de Fauna Andina Eduardo Avaroa
Best visited together, the world's largest salt lake and this stunning high-altitude reserve have a desolate, otherworldly beauty.
The highest city on earth has a tragic history, stunningly preserved colonial architecture and a legendary silver mine.
Bolivia's most appealing city has a welcoming atmosphere, atmospheric whitewashed buildings, leafy plazas, and a year-round spring-like climate.
7 The Jesuit missions of Chiquitos
These Jesuit-founded towns in remote eastern Bolivia boast a series of stunning churches and a fascinating history.
8 Rurrenabaque and the Amazon
Perfectly sited on the Río Beni, buzzing Rurrenabaque has the biodiverse wonders of the Amazon on its doorstep.