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From the bustling historic center to the tranquil hills across the Arno, this article will guide you through Florence's many districts, helping you find the perfect base for your Tuscan adventure. Whether you're seeking proximity to major attractions, a taste of local life, or a peaceful retreat, we'll explore which is the best area to stay in Florence to make the most of your trip.
Florence has something for everyone, depending on what you’re after. If your trip to Italy includes a first-time stop in the city, stay near the Duomo. It is the historic heart of Florence, dominated by the Cathedral of Santa Maria del Fiore. You will be close to major sights, shops, and restaurants, although the area is often crowded and more expensive.
For a more local vibe, head to San Frediano in the Oltrarno district. It is known for artisan workshops, small markets, and a more authentic feel with fewer tourists.
Santa Maria Novella is a good choice for families. The area is flat, which makes it easy to navigate with strollers, and it is close to the main train station for convenient day trips. You will also find open spaces and family-friendly places to stay.
Couples should consider Santo Spirito, also in Oltrarno. This romantic neighborhood has inviting piazzas, great restaurants, and a slower pace that suits evening strolls and relaxed dinners.
If culture is your focus, stay near the Uffizi, where the city’s top museums are within walking distance. For nightlife, Santa Croce has bars, clubs, and live music, though it can be noisy at night.
If you are looking for something more exclusive, Piazzale Michelangelo offers sweeping views of Florence and a quieter, more upscale place to stay.
Not sure how long to stay in Florence? Your choice of neighborhood can help shape your itinerary.

David of Michelangelo in Accademia Gallery of Florence, Galleria dell'Accademia, Italy © Shutterstock
If you're looking for an authentic Florentine experience, San Frediano is the place to be. This charming neighborhood on the Oltrarno side of Florence is famous for its genuine Florentine atmosphere and artisan workshops. Here’s how to make the most of your visit:
Start your exploration with the Basilica di Santo Spirito, a stunning Renaissance church designed by Brunelleschi. Then, head over to the Palazzo Pitti, a grand Renaissance palace housing several fascinating museums. Don't miss the Cappella Brancacci in the Church of Santa Maria del Carmine, where you can admire the incredible frescoes by Masaccio and Masolino.
San Frediano has a distinctly local and laid-back vibe, offering a peek into the daily lives of Florentines. The narrow streets are filled with traditional trattorias, charming small shops, and artisan workshops where you can watch craftsmen at work.
On the last Sunday of each month, don’t miss the Fierucola, an organic farmers' market in Piazza Santo Spirito, where you can buy local produce and crafts.
Why I love it: San Frediano is where you can experience the real Florence, away from the tourist crowds.
Browse hundreds of accommodations in San Frediano to fit any budget.

Bargello Palace, Florence © Timur Kulgarin/Shutterstock
The Duomo neighborhood is in the center Florence, dominated by the iconic Cathedral of Santa Maria del Fiore with its massive dome engineered by Brunelleschi. This area is packed with must-see attractions like Giotto's Bell Tower, the Baptistery of San Giovanni with its famous bronze doors, and the Museo dell'Opera del Duomo, where you can see many of the original artworks from these historic monuments.
The bustling Piazza della Repubblica is also a key spot, and from here, you’re within walking distance of the Galleria dell'Accademia, home to Michelangelo's David.
For an unforgettable experience, climb to the top of the Duomo or Bell Tower for breathtaking panoramic views of Florence. Shop along the fashionable Via de' Tornabuoni or visit the Palazzo Medici Riccardi to see the stunning Chapel of the Magi.
Streets radiate out from the cathedral in a medieval pattern, filled with a mix of high-end shops, historic cafes, and souvenir stores (the charming artisan shops in the nearby Oltrarno district across the Ponte Vecchio are a favorite). While it can be crowded with tourists, especially during peak seasons, the area maintains its Renaissance charm.
Why I love it: The Duomo area is lively and vibrant, with a constant buzz of activity.
Browse hundreds of accommodations in Duomo to fit any budget.

Piazza della Repubblica in Florence © Shutterstock
Looking for the best area to stay in Florence with your family? Santa Maria Novella is a convenient and family-friendly neighborhood in Florence, centered around the stunning Santa Maria Novella church, a masterpiece of Gothic and early Renaissance architecture.
Santa Maria Novella is relaxed, a nice contrast to the busier Duomo area. The wide, pedestrian-friendly streets and open squares give kids plenty of space to move around. Plus, the proximity to the main train station makes day trips super convenient. The neighborhood still feels local, with markets, shops, and cafes that cater to both residents and visitors.
There's more to explore, too. For some outdoor fun, head to Cascine Park, Florence's largest green space, perfect for picnics and a hit with the kids. And be sure to spend some time at the charming Piazza Santa Maria Novella, where children can run around while you relax at a café.
Why I love it: It's a neighborhood where you can start your day with a leisurely breakfast in a bustling piazza, explore world-class art and architecture, and end with a stroll through peaceful gardens.
Browse hundreds of accommodations in Santa Maria Novella to fit any budget.

Cathedral of Santa Maria del Fiore and Baptistery of St. John Battistero di San Giovanni, Florence © Shutterstock
Santo Spirito, located in the Oltrarno district, is a charming neighborhood centered around the Piazza Santo Spirito and its eponymous church designed by Brunelleschi. One of the main highlights here is the Basilica di Santo Spirito, where you can admire a stunning wooden crucifix by Michelangelo.
Strolling through the cobblestone streets lined with medieval buildings is pure magic, especially for couples. Take a leisurely browse along Via Maggio, famous for its antiques and handmade goods.
For a romantic dining experience, try La Casalinga for cozy, traditional Tuscan cuisine, or opt for an upscale evening at Il Santo Bevitore, known for its excellent wine list. Start your evening with aperitivo at Volume, a trendy café-bar in Piazza Santo Spirito, or enjoy craft cocktails at Rasputin, an intimate speakeasy-style bar.
A stroll through the Rose Garden offers breathtaking panoramic views of Florence, making it a perfect romantic spot. For a quieter art experience, visit the lesser-known Museo Bardini or the eclectic Museo Stefano Bardini. And for a special treat, book a couple's spa day at Soul Space, a beautiful wellness center housed in a historic palazzo.
Why I love it: The area's laid-back vibe and stunning architecture create an incredibly romantic atmosphere.
Browse hundreds of accommodations in Santo Spirito to fit any budget.

Palazzo Pitti and Boboli gardens in Florence © Lucy/Shutterstock
Welcome to the Uffizi area, named after the world-renowned Uffizi Gallery. This neighborhood is packed with artistic and historical treasures. The Uffizi Gallery itself is a must-see, housing masterpieces by Botticelli, Leonardo da Vinci, Michelangelo, and more.
Just a short walk away, you'll find the Palazzo Vecchio, Florence's impressive town hall, where you can dive into the city's political history and admire stunning Renaissance interiors. The area also includes the Piazza della Signoria, an open-air sculpture gallery featuring iconic works like the replica of Michelangelo's David.
Don't miss a visit to the Bargello National Museum, home to important Renaissance sculptures, or the Galileo Museum, dedicated to fascinating scientific instruments. For a unique perspective, stroll along the Corridoio Vasariano, the elevated passageway connecting Palazzo Vecchio to Palazzo Pitti. If you're into music, catch a concert at the Church of Orsanmichele, a former granary turned church with a rich artistic heritage.
Coffee lovers should definitely stop by Caffè Gilli, one of Florence's oldest cafes, for an authentic Italian coffee experience.
Why I love it: Uffizi is the perfect base for culture enthusiasts who want to immerse themselves in the Renaissance spirit that shaped Florence.
Browse hundreds of accommodations in Uffizi to fit any budget.

The best area to stay in Florence for many is Uffizi
Santa Croce is one of Florence's liveliest neighborhoods, anchored by the stunning Basilica di Santa Croce, the largest Franciscan church in the world. This basilica is also the final resting place of Michelangelo, Galileo, and Machiavelli.
If you're a fan of cocktails, you have to visit Negroni, named after the famous Florentine cocktail. This bar specializes in creative variations of the classic drink and offers a sophisticated atmosphere.
Locale Firenze is also a must-visit. This cocktail bar in a Renaissance palazzo serves innovative drinks in a stunning setting. Another great spot for aperitivo is Ditta Artigianale, which transforms from a trendy café by day to a vibrant bar by night. For live music, Café Caracol is a popular choice among locals. For a taste of traditional Florentine cuisine before your night out, try Osteria de' Benci.
And if you're in the mood for dancing, head to Soul Kitchen. This vibrant club features DJ sets and dancing, and it's particularly popular among the younger crowd, known for its energetic atmosphere and mix of electronic and pop music.
Why I love it: Santa Croce is where you can admire Renaissance masterpieces by day and dance the night away in centuries-old palazzos turned into chic clubs by night
Browse hundreds of accommodations in Santa Croce to fit any budget.

The frescoes in the Church of Santa Croce in Florence © Frnco Volpato/Shutterstock
When you're in Florence, one spot you absolutely have to visit is Piazzale Michelangelo. It's famous for its breathtaking views of the city. Built in the 19th century, this plaza features bronze replicas of Michelangelo's David and the Medici Chapel sculptures.
The vibe around Piazzale Michelangelo is all about refined tranquillity. Here you’ll find winding streets shaded by cypress trees, lined with elegant villas – it’s an exclusive slice of Florence. As the sun sets, the area becomes romantic with the city lights twinkling below.
When it comes to dining, you’ve got some stellar options. La Loggia Restaurant at Villa San Michele serves up gourmet cuisine with amazing panoramic views. If you’re in the mood for cocktails, head to the rooftop bar at Plaza Hotel Lucchesi – the vistas are unbeatable. For a casual yet upscale meal, check out La Bottega del Buon Caffè, a Michelin-starred restaurant at the base of the hill, known for its innovative Tuscan dishes.
Explore the Bardini Gardens nearby, a hidden gem featuring baroque staircases and lush fruit orchards.
Why I love it: Piazzale Michelangelo offers an unparalleled blend of breathtaking views, tranquil surroundings, and proximity to some of the city's most exclusive experiences.
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written by
Dre Roelandt
updated 11.04.2025
Dre Roelandt is originally from the United States but lives and works in Berlin, Germany. Dre is a freelance writer and artist with a passion for travelling. They are an in-house Senior Content Editor at Rough Guides.
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