Beaune, the principal town of the Côte d’Or, manages to maintain its attractively ancient air, despite a near-constant stream of wine aficionados using the place as their base. Narrow cobbled streets and sunny squares dotted with cafés make it a lovely, albeit expensive, spot to sample the region’s wine. Beaune’s chief attraction is the fifteenth-century hospital, the Hôtel-Dieu, founded in 1443 by chancellor of Burgundy, Nicholas Rolin. As grateful ex-patients or their families donated vine plots to the hospital, the town prospered quickly to become the centre of the local wine trade. The cobbled courtyard is surrounded by a wooden gallery overhung by a massive roof patterned with diamonds of variegated tiles – green, burnt sienna, black and yellow – and similarly multicoloured steep-pitched dormers and turrets. Inside is a vast paved hall with a glorious arched timber roof, the Grande Salle des Malades, with the original enclosed wooden beds. Passing through two smaller, furnished wards, one with some stunning seventeenth-century frescoes, then the kitchen and the pharmacy, you reach a dark chamber housing the splendid fifteenth-century altarpiece of the Last Judgement by Rogier van der Weyden and the tapestry of St Eloi, which is comparable to the Lady and the Unicorn in the Musée National du Moyen Age in Paris.