Buses make the short journey to Manuel Antonio every half-hour from 7am to 7pm (20min), departing from the main terminal. Buses also head north from here to San José (9–10 daily) and Puntarenas (6 daily), via Jacó, as well as south to Dominical and Uvita (depart 5.30am, 11.30am & 1.30pm). Taxis line up at the rank at the south end of the mercado; the journey to Manuel Antonio costs $14.
If you’re driving, you can get to San Isidro, Golfito, the Osa Peninsula and other points in the Zona Sur via Dominical, 44km south of Quepos – although the road is usually in terrible condition and you’ll need a sturdy 4WD, it beats going all the way back to San José and taking the Interamericana south.
You can fly direct from Quepos to San José (8 daily; 25min) and La Fortuna (daily 40min); for tickets and schedules, visit Lynch Tours.